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Nonclinical toxicology studies GLP-compliant repeat-dose toxicity studies were conducted in cynomolgus monkeys (Macaca fascicularis

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In addition, these workers found that antidepressant treatment may lead to defective spindle assembly and altered organelle distribution, with changes in the protein concentrations of small C-terminal domain phosphatases-1 and -3, nuclear mitotic apparatus (NuMa), and calnexin occurring during cell division in vitro