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This live bacterial cell assay provides an accurate and rapid means of screening for enzyme activity change resulting from human mutations, offering insights into the causality of genetic disorders attributable to genetic variations

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Figure 4 Figure 5 3.2 RLR-IFN-I signaling pathway Other than TLR7 and TLR9, RLRs, including RIG-I, melanoma differentiation-associated gene 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2), serve as intracellular PRRs mainly involved in antiviral immune responses (54)